Harvey Fineberg is a physician, scholar, public policy researcher, and administrator. Born in 1945 and raised in Pittsburgh, Pennsylvania, he earned his AB, MD, master's degree in public policy, and PhD in Government from Harvard University. Fineberg was appointed assistant professor at the Harvard School of Public Health and later served as the dean from 1984 to 1997, becoming provost of Harvard in 1997. During his academic career, Fineberg consulted for the federal government and worked for the American Foundation for AIDS Research, the World Health Organization, and served on numerous academic advisory committees and boards of foundations. Fineberg retired from Harvard and served as the president of the Institute of Medicine from 2002 until 2014. In 2014-15, Fineberg assumed the presidential chair in medicine at UC San Francisco. He was recruited to be president of the Gordon and Betty Moore Foundation in 2015 and served as interim chief program officer of the Patient Care Program. He also continued working at the intersection of public policy and public health with the National Academy of Medicine and the Standing Committee on Emerging Infectious Diseases and 21st Century Health Threats. In this interview, Fineberg discusses his upbringing and education, his career in medicine and patient care, his leadership roles, and the history, structure, and the potential of the Gordon and Betty Moore Foundation.