Edward Penhoet is a biochemist who, at the Gordon and Betty Moore Foundation, served as Chief Program Officer for Science and Higher Education (2002-2004), President (2004–2008), and member of its board of trustees (2004–2011). Penhoet was born in December 1940 in Oakland, California, and earned his undergraduate degree in Biology from Stanford University in 1963. He earned his PhD in Biochemistry in 1968, initially at the University of Illinois Urbana- Champaign, and ultimately from University of Washington. After becoming a postdoctoral fellow at UC San Diego from 1968 to 1970, Penhoet joined the faculty of the Biochemistry Department at UC Berkeley. In 1981, with William J. Rutter and Pablo Valenzuela, Penhoet cofounded the early biotechnology company Chiron Corporation, where he was president and CEO. From 1998 to 2002, Penhoet was Dean of the School Public Health at UC Berkeley. In 2002, Penhoet joined the Gordon and Betty Moore Foundation as its Chief Program Officer for Science and Higher Education. He was president of the foundation from 2004 to 2008, and he served on its board of trustees until 2011. In this oral history, Penhoet focuses on his time with the Gordon and Betty Moore Foundation. He discusses early staff leadership; the foundation's focus on outcomes and measurement; its initial location in the Presidio of San Francisco and its later move to Palo Alto; early funding in science, environmental conservation, and patient care; as well as his personal interactions with the Moore family.