Prof. Michael Romalis, Dept. of Physics, Princeton University, describes recent advances in the ultra-sensitive alkali-metal and noble gases magnetometers that allow them to compete in sensitivity and spatial resolution with most sensitive SQUID magnetometers. Several applications of such magnetometers for tests of fundamental symmetries, detection of biological magnetic fields, and NMR are discussed. They have developed a self-compensating co-magnetometer using an alkali-metal and a noble gas that is only sensitive to anomalous spin couplings beyond the Standard Model, which can be caused, for example, by non-commutativity of space-time. They have also demonstrated localization of magnetic fields using a multi-channel magnetometer and are developing a system for mapping of the magnetic fields generated by the brain.