Keith Yamamoto is Professor, Vice Chancellor for Science Policy and Strategy, and Director for Precision Medicine at UCSF, where he oversees strategic planning as well as research activities. After earning a PhD at Princeton, he came to UCSF in 1973. He served as chair of the Department of Cellular and Molecular Pharmacology from 1994 to 2003. Dr. Yamamoto is regarded as an international leader in studying the mechanisms of signaling and gene regulation by intracellular receptors. In this interview, Dr. Yamamoto discusses the following topics: meeting and getting to know Herb and Marion Sandler; the development and expansion of the Program in Breakthrough Biomedical Research (PBBR); and the achievements and future promise of PBBR. Note that the Oral History Center has interviewed Dr. Yamamoto twice before in oral histories in which he recounts the full sweep of his career in research and administration.