Daniel Klein was born and raised on Long Island, New York. He attended Dartmouth as an undergraduate and then Cornell Medical School. His interest in internal medicine, as well as social justice aspects of health care, took him to the University of New Mexico for a residency in which he worked closely with Native American Indians. He then served in the US Public Health Service in San Francisco, where he encountered the sexual revolution and counterculture as a physician. After a short stint in private practice, in 1983 Dr. Klein joined the Permanente Medical Group at the Hayward hospital where he specialized in infectious disease. Dr. Klein soon became the on-site HIV/AIDS specialist. In this interview, Dr. Klein discusses the treatment of people with HIV/AIDS within Kaiser Permanente, the organizational response to the epidemic, and the transformation of his practice with the emergence of effective antiviral medications in the 1990s. Approximately 2 hours, 30 minutes; video interview conducted by Martin Meeker.