George Matula attended Swarthmore College as an undergraduate and then medical school at Temple University. He engaged in post-graduate work at the University of Illinois, University of Michigan, and Northwestern, and spent a year on the Berry Plan at Camp Pendleton. Matula worked as a staff physician at Kaiser Permanente San Francisco in the 1970s where he was first exposed to the medical dimensions of sexual subcultures. While serving as Interim Chief of Infectious Diseases at UCSF in 1981, Matula encountered some of the earliest cases of AIDS in the United States. In this interview, Dr. Matula discusses the response by Kaiser Permanente to the AIDS epidemic in San Francisco. He also details his participation in the AIDS Clinical Trials Group with the Stanford Medical Center as a Kaiser Permanente physician and the development of treatment regimens beginning with AZT in the late 1980s. Approximately 6 hours, 40 minutes; video interview conducted by Martin Meeker.