Harold G. Scheie was an ophthalmologist who was both a successful educator and clinician, and pioneered treatment of several eye conditions. He was born and raised in South Dakota, and received his undergraduate and medical degrees at the University of Minnesota. After serving in the Army Medical Corps, he returned to teach at the University of Pennsylvania, where he became the chairman of the ophthalmology department at the University’s medical school from 1960-1975. He developed surgical procedures for the treatment of congenital cataracts and glaucoma, and identified a rare genetic condition that affects the corneas, now called Scheie’s syndrome. He also founded the Scheie Eye Institute. In this interview, Scheie discusses all this as well as his internship and residency at the University of Pennsylvania (UP) Hospital, 1935-1940; private practice with Francis Heed Adler; his acquaintance with Noel Coward, Stewart Duke-Elder, Patrick J. Hurley, Elias Potter Lyon, Louis Mountbatten, Soong sisters, and General Stilwell; Crile Army Hospital Eye Center, Cleveland, OH; design, construction, and funding of the Scheie Eye Institute; research in medical ophthalmology; consultancies; medical organization memberships; and his publications and honors.