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Family, education, studies at MIT; graduate work in mechanical engineering, UC Berkeley; hydraulics research and consultations, 1928-1941: contributions to coastal engineering, Pacific Coast Survey; WWII, consulting for armed services, Manhattan Project, E. O. Lawrence, Robert Oppenheimer, Engineering Science and Manpower War Training program, Bikini Atoll bomb tests; Dean of College of Engineering, UC Berkeley, 1943-1958: campus politics, faculty recruitment, post-war expansion of graduate education, facilities, research units, institutes; Loyalty Oath controversy, committee and tenure systems, University presidents Sproul and Kerr; consulting engineer, General Electric, 1947-1988: jet engine design, nuclear power, GE's relations with government, research and development issues for large companies, university-government-industry relationship, problem-solving; advisory posts. Appendices include writings by O'Brien and material from notebooks and files.

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