John Gofman is a scientist known for both his work on the Manhattan Project and his study of lipoproteins and heart disease. He received his B.A. in Chemistry from Oberlin College in 1939, then entered UC Berkeley to earn his PhD in chemistry and work on the Manhattan Project. As part of his dissertation research, he discovered four radioisotopes, including uranium-233, which he also proved was fissionable. He also helped develop two techniques for plutonium separation, variations of which were used at the Hanford Site. He earned his PhD in 1943 and his M.D. in 1946, and in 1947 became a professor in U.C. Berkeley’s medical physics department. During his time as a professor, he studied lipoproteins and their connection to heart disease, and he is now known as the “father of clinical lipidology.” In this interview, Gofman discusses his education in chemistry and medicine, research on heart disease and radiation effects, his associations with Donner Laboratory and Lawrence Livermore Laboratory, and his concerns about the human health risks of radiation.