Understanding binding affinities of transcription factor (TF) proteins to DNA sequence is crucial to the identification of regulatory regions that control differential gene expression across cell types. Recent advancements in ChIP-sequencing (ChIP-seq) allow us to accurately identify binding sites for a specific TF in a cellular context of interest. However, running a separate assay for each of the thousands of known TFs for a new cell type of interest is time and cost-intensive, thus motivating the need for an efficient computational method to infer experimental results of unknown experiments using prior information gathered from experiments on robustly annotated cell types. We propose an attention-based deep learning approach for learning the minimal set of epigenetic experiments required to accurately quantify transcription factor (TF) binding sites from DNA sequence.
Title
Epigenetic Imputation
Published
2018-05-17
Full Collection Name
Electrical Engineering & Computer Sciences Technical Reports
Other Identifiers
EECS-2018-71
Type
Text
Extent
27 p
Archive
The Engineering Library
Usage Statement
Researchers may make free and open use of the UC Berkeley Library’s digitized public domain materials. However, some materials in our online collections may be protected by U.S. copyright law (Title 17, U.S.C.). Use or reproduction of materials protected by copyright beyond that allowed by fair use (Title 17, U.S.C. § 107) requires permission from the copyright owners. The use or reproduction of some materials may also be restricted by terms of University of California gift or purchase agreements, privacy and publicity rights, or trademark law. Responsibility for determining rights status and permissibility of any use or reproduction rests exclusively with the researcher. To learn more or make inquiries, please see our permissions policies (https://www.lib.berkeley.edu/about/permissions-policies).