In this thesis, I discuss three prediction serving systems designed to meet the needs of modern interactive machine learning applications. The key idea in this work is to utilize a decoupled, layered design that interposes systems on top of training frameworks to build low-latency, scalable serving systems. Velox introduced this decoupled architecture to enable fast online learning and model personalization in response to feedback. Clipper generalized this system architecture to be framework-agnostic and introduced a set of optimizations to reduce and bound prediction latency and improve prediction throughput, accuracy, and robustness without modifying the underlying machine learning frameworks. And InferLine provisions and manages the individual stages of prediction pipelines to minimize cost while meeting end-to-end tail latency constraints.