Monitoring for cancer recurrence after initial therapy is challenging. Current imaging technology limits the size at which cancer may be detected; currently, the smallest clinically detectable tumor is 1-2 mm in diameter [1,20]. A locally recurrent tumor of this size has a high chance for metastatic dissemination, which could render the patient incurable [2]. In collaboration with oncologist researchers from Washington State University and UC-San Francisco, we propose a modern cancer surveillance technique that utilizes a radiation-detecting micro-sensor employed with radiolabeled inhibitor-based anti-body drug conjugates (ADC’s) for the localization of prostate cancer. To achieve molecular identification and localization, a network of CMOS image sensors will be used to localize tumor growth at early stages. As preliminary design steps, this project report identifies and analyzes system constraints to establish a theoretical framework for such a design. Based on data presented in this study, simulations suggest that two 500 x 500 um2 stacked CMOS Active Pixel Sensors (APS) with a 500 um separation could be used to localize a tumor with a 300 um radius up to 5mm from the sensor interface.




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