We are in world where autonomous systems, such as self-driving cars, surgical robots, robotic manipulators are becoming a reality. Such systems are considered safety-critical since they interact with humans on a regular basis. Hence, before such systems can be integrated into our day to day life, we need to guarantee their safety. Recent success in machine learning (ML) and artificial intelligence (AI) has led to an increase in their use in real world robotic systems. For example, complex perception modules in self-driving cars and deep reinforcement learning controllers in robotic manipulators. Although powerful, they introduce an additional level of complexity when it comes to the formal analysis of autonomous systems. In this thesis, such systems are designated as Learning-Based Cyber-Physical Systems~(LB-CPS).

In this thesis, we take inspiration from the Oracle-Guided Inductive Synthesis~(OGIS) paradigm to develop frameworks which can aid in achieving formal guarantees in different stages of an autonomous system design and analysis pipeline. Furthermore, we show that to guarantee the safety of LB-CPS, the design (synthesis) and analysis (verification) must consider feedback from the other. We consider five important parts of the design and analysis process and show a strong coupling among them, namely (i) Robust Control Synthesis from High Level Safety Specifications; (ii) Diagnosis and Repair of Safety Requirements for Control Synthesis; (iii) Counter-example Guided Data Augmentation for training high-accuracy ML models; (iv) Simulation-Guided Falsification and Verification against Adversarial Environments; and (v) Bridging Model and Real-World Gap. Finally, we introduce a software toolkit VERIFAI for the design and analysis of AI based systems, which was developed to provide a common formal platform to implement design and analysis frameworks for LB-CPS.